Melanotan is trending again. As a dermatologist, I strongly need to tell you , Its an unapproved injectable peptide, and were seeing:, nausea and flushing, darkening of existing moles, Your body already makes a hormone that tells your skin to tan. Melanotan 2 is a synthetic peptide engineered to mimic that hormone but in a version that's more potent and longer lasting than Is this injectable tanning drug safe to use? An overview of benefits and risks of chronic melanocortin1 receptor activation Bhm 2025 Journal of the European Academy of Dermatology and Venereology Wiley Online Library