Labial melanotic macule Melanocytic Lesions A Guide to Clinical Differential Diagnosis of Oral Mucosal Lesions Continuing Education Course dentalcare.com This lovely patient was thrilled with her beautiful result after laser treatment of oral melanotic macules. I share this case to educate: laser treatment requires accurate diagnosis, an understanding of the differential This patient has multiple labial melanotic macules. These are essentially freckles of the lips. These most commonly involve the lower lip. This patient had involvement of both the upper and lower lips.