What is the optimal site for intramuscular (IM) vitamin B12 injections? B12 Injections in Sacramento, CA LUX Wellness Safe intramuscular (IM) injection in the gluteal region is given in the upper outer quadrant to avoid sciatic nerve injury. Incorrect site selection (inner, lower, or medial areas) increases the risk of Administering a B12 Injection Safely and Professionally
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