Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect Acetaminophen can lower glutathione and use sulfate. V@ccine adjuvants like aluminum intentionally stimulate the immune system. Stacking these in sensitive windows can raise inflammatory load in Frontiers Herbal Therapy for the Treatment of Acetaminophen Associated Liver Injury: Recent Advances and Future Perspectives