Phospholipase C, Phosphatidylinositol specific from Bacillus cereus Physiologic implications of phosphoinositides and phospholipase C in the regulation of insulin secretion. Semantic Scholar Frontiers Phospholipase C: underrated players in microbial infections This diagram illustrates a signaling pathway in which a messenger molecule binds to a receptor on the cell membrane, activating an associated G protein. Once triggered, the G protein's subunit exchanges GDP for GTP